422625 Sigma-AldrichKLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem
The KLF5 Inhibitor, CID 5951923 controls the biological activity of KLF5.
More>> The KLF5 Inhibitor, CID 5951923 controls the biological activity of KLF5. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
- SDS
- CoA
- References
- Data Sheet
Synonyms: 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate
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Overview
| Replacement Information |
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Key Specifications Table
| CAS # | Empirical Formula |
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| 749872-43-3 | C₁₆H₁₈N₂O₇S |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 422625-10MG |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182. |
| Catalogue Number | 422625 |
| Brand Family | Calbiochem® |
| Synonyms | 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate |
| References | |
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| References | Bialkowska, A., et al. 2011. Mol. Cancer Ther. 10, 2043. |
| Product Information | |
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| CAS number | 749872-43-3 |
| Form | Off-white solid |
| Hill Formula | C₁₆H₁₈N₂O₇S |
| Chemical formula | C₁₆H₁₈N₂O₇S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Purity | ≥99% by HPLC |
| Physicochemical Information |
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| Dimensions |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Storage and Shipping Information | |
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| Ship Code | Ambient Temperature Only |
| Toxicity | Standard Handling |
| Storage | +2°C to +8°C |
| Protect from Light | Protect from light |
| Do not freeze | Ok to freeze |
| Special Instructions | Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C. |
| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 422625-10MG | 04055977187199 |
Documentation
KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem SDS
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KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 422625 |
References
| Reference overview |
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| Bialkowska, A., et al. 2011. Mol. Cancer Ther. 10, 2043. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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